PUBLICATIONS 

Abstracts

1. Nathanael Matei, James Burford; Sophie Leahy; Selin L Auvazian; Biju Thomas; Norman P Blair; Mahnaz Shahidi, The effect of reduced oxygen delivery and metabolism on electroretinogram b-wave in rats, ARVO Annual Meeting Abstract.2019. Link:  https://iovs.arvojournals.org/article.aspx?articleid=2745191&resultClick=1 

2. Nathanael Matei, Sophie Leahy, Selin Auvazian, Norman P. Blair, Mahnaz Shahidi. Retinal Oxygen Metabolic, Anatomical, and Biochemical Changes in Experimental Carotid Artery Occlusion. Abstract. Stroke Conference. 2020. https://www.ahajournals.org/doi/10.1161/str.51.suppl_1.WP165 

3. Nathanael Matei, Sophie Leahy, Norman P. Blair, Mahnaz Shahidi, Long-term Reperfusion Effects on Retinal Oxygen Delivery, Metabolism, Extraction Fraction, and Function after Ophthalmic Vessel Occlusion in Rats. Abstract. IOVS. 2020

4. J Jason McAnany; Nathanael Matei; Karen Liu; Jason C Park; Mahnaz Shahidi. Inner-retina dysfunction in the 5xFAD mouse model of Alzheimer’s disease assessed by electroretinography. Abstract. IOVS. 2020.   https://iovs.arvojournals.org/article.aspx?articleid=2768333&resultClick=1

First Author: Literature Review

1. Nathanael Matei, Justin Camara, John H. Zhang, “The next step in the treatment of stroke,” Expert Opinion on Investigational Targets. 2020. https://doi.org/10.3389/fneur.2020.582605  

2. Nathanael Matei, Richard Camara, John H. Zhang. Challenging the current stroke paradigm: A review of delayed recanalization. 2021. https://doi.org/10.1177/0271678X20978861 

3. Nathanael Matei, Jiping Tang, John H. Zhang, “The Scientific Premise, Emerging Mechanisms, and Novel Applications of Hydrogen Gas Therapy,” Medical Gas Research. 2018. https://pubmed.ncbi.nlm.nih.gov/30319764/ 

First and Senior Author: Manuscripts (Data based)

1. Nathanael Matei, Sophie Leahy, Normal P Blair, James Burfard, Mansour Rahimi, Mahnaz Shahidi.  Prophylactic Effects of Creatine and Metformin after Incomplete Retinal Ischemia. Scientific Reports. 2023. (In revisions)

2. Nathanael Matei, Sophie Leahy, Normal P Blair, James Burfarc, Mansour Rahimi, Mahnaz Shahidi. Retinal Vascular Physiology Biomarkers in a 5XFAD Mouse Model of Alzheimer’s Disease. Cells. 2022. https://www.mdpi.com/2073-4409/11/15/2413/html 

3. Nathanael Matei, Leahy S, Blair NP, Shahidi M. Assessment of retinal oxygen metabolism, visual function, thickness and degeneration markers after variable ischemia/reperfusion in rats. Experimental eye research 2021. https://doi.org/10.1016/j.exer.2021.108838 

4. Nathanael Matei, Justin Camara, Devin McBride, Richard Camara, Jiping Tang, John H. Zhang, “Intranasal wnt3a attenuates neuronal apoptosis through Frz1/PIWIL1a/FOXM1 pathway in MCAO rats,” Journal of Neuroscience. 2018. https://doi.org/10.1523/JNEUROSCI.2352-17.2018 

5. Nathanael Matei, Sophie Leahy, Selin Auvazian, Biju Thomas, Norman P. Blair, Mahnaz Shahidi, “Relation of Retinal Oxygen Measures to Electrophysiology and Survival Indicators after Permanent, Incomplete Ischemia in Rats.” 2020. Translational Stroke Medicine. https://pubmed.ncbi.nlm.nih.gov/32207038

6. Nathanael Matei, James Burford, “The Effect of Ischemia and Reperfusion on Retinal Oxygen Measures, Electrophysiology, and Survival after Ophthalmic Vessel Occlusion in Rats”. 2021. Experimental Eye Research. https://doi.org/10.1016/j.exer.2021.108838

7.  Mahnaz Shahidi, Amir Nankali, Anthony E Felder, Mansour Rahimi, Sophie Leahy, Nathanael Matei. Alterations in retinal pulse wave velocity under experimental ocular hypertension. 2023 Jul. Microvasc Res. https://pubmed.ncbi.nlm.nih.gov/37024073/ 

Middle Authorship:

8. Yan Zhang, Qiuyang Su, Guofeng Wu, Nathanael Matei, Shengling Zeng. Activation of PARP in secondary brain injury following intracerebral haemorrhage. 2024 Brain Hemmorhages. DOI: https://www.sciencedirect.com/science/article/pii/S2589238X24000731?via%3Dihub  

9. Jing Yua,b, Jinlan Lia, Nathanael Matei, Wenna Wanga, Lihui Tanga, Jinwei Pang, Xue Lia, Lili Fanga, Jiping Tangb, John H. Zhangb, Min Yana. Intranasal administration of recombinant prosaposin attenuates neuronal apoptosis through GPR37/PI3K/Akt/ASK1 pathway in MCAO rats. 2023 Exp Neurology. DOI: https://www.sciencedirect.com/science/article/abs/pii/S0014488623003412?dgcid=coauthor 

10. Blair NP, Matei N, Leahy S, Rahimi M, Shahidi M. The accumulated oxygen deficit as an indicator of the ischemic retinal insult. Experimental Eye Research. 2023 May. https://pubmed.ncbi.nlm.nih.gov/36931487/ 

11. Felder AE, Rahimi M, Nankali A, Matei N, Abdolahi F, Blair NP, Shahidi M. A retinal imaging system for combined measurement of optic nerve head vascular pulsation and stimulated vasodilation in humans. Scientific reports. 2023 Oct. https://pubmed.ncbi.nlm.nih.gov/37816947/ 

12. Mansour Rahimi, Sophie Leahy, Nathanael Matei, James Burford, Norman P Blair, Mahnaz Shahidi. Impairments of retinal hemodynamics and oxygen metrics in ocular hypertension-induced ischemia-reperfusion. Exp Eye Res. 2022 Dec. https://pubmed.ncbi.nlm.nih.gov/36252653/. 

13. Mansour Rahimi, Sophie Leahy, Nathanael Matei, Norman P Blair, Shinwu Jeong, Cheryl Mae Craft, Mahnaz Shahidi. Assessment of inner retinal oxygen metrics and thickness in a mouse model of inherited retinal degeneration. 2021. Experimental Eye Research. https://pubmed.ncbi.nlm.nih.gov/33539865/ 

14. Sophie Leahy, Nathanael Matei,  Norman P. Blair, and  Mahnaz Shahidi. Retinal Oxygen Delivery and Metabolism Response to Hyperoxia During Bilateral Common Carotid Artery Occlusion in Rats. 2022. IOVS. https://pubmed.ncbi.nlm.nih.gov/35767246/ 

15. Hui Liang, MD; Nathanael Matei; Devin W. McBride, MD; Yang Xu, MD; Zhenhua Zhou, MD; Jiping Tang, MD; John H. Zhang, MD, PhD. TGR5 Activation Attenuates Neuroinflammation Via Pellino3 Inhibition of Caspase-8/NLRP3 after MCAO in Rats. Journal of Biomedical Sciences. 2021. Journal of Neuroinflammation. https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-021-02087-1

16. J Jason McAnany, Nathanael Matei, Yi-Fan Chen, Karen Liu, Jason C Park, Mahnaz Shahidi. Rod pathway and cone pathway retinal dysfunction in the 5xFAD mouse model of Alzheimer's disease. Scientific Reports. 2021.https://pubmed.ncbi.nlm.nih.gov/33649406/

17. Chao Pan, Qi Li, Nathanael Matei and Zhouping Tang. Minimally invasive puncture and subsequent fibrinolytic therapy for hematoma evacuation: A case report. 2020. Brain Hemorrhages. https://doi.org/10.1016/j.hest.2021.02.001

18. Norman P Blair, Sophie Leahy, Nathanael Matei, Mahnaz Shahidi. Retinal Blood Flow During Alternative Circulatory Pathways to the Rat Eye. Experimental Eye Research. 2020. https://linkinghub.elsevier.com/retrieve/pii/S001448352030347X

19. Mansour Rahimi, Sophie Leahy, Nathanael Matei, Norman P. Blair, Shinwu Jeong, Cheryl Mae Craft Mahnaz Shahidi. Assessment of Inner Retinal Oxygen Metrics and Thickness in a Mouse Model of Retinitis Pigmentosa. IOVS. 2020. https://pubmed.ncbi.nlm.nih.gov/33539865/

20. Jinwei Pang1,2, Nathanael Matei3, Richard Camara3, Wen Zheng3, Yu Jing3, Xu Luo3, Jiping Tang3, John H. Zhang3⁎, Yong Jiang1,2⁎⁎Jing Yu; Nathanael Matei; Xue Li; Jinwei Pang; Jun Mo; Shengpan Chen; Jiping Tang; Min Yan; John Zhang. Macrophage Infiltration Improves Stroke Recovery after Delayed Recanalization in Rats.Oxid Med Cell Longev. 2022. https://pubmed.ncbi.nlm.nih.gov/36035227/  

21. Jing Yu; Nathanael Matei; Xue Li; Jinwei Pang; Jun Mo; Shengpan Chen; Jiping Tang; Min Yan; John Zhang. Ezetimibe attenuates oxidative stress and neuroinflammation through inhibition of NLRP3 inflammasomes via the AMPK/Nrf2/TXNIP pathway in MCAO rats. Oxidative Medicine and Cellular Longevity. 2020. https://doi.org/10.1155/2020/4717258 

22. Jing Yu, Nathanael Matei, Jun Mo, Jinwei Pang, Shengpan Chen, Jiping Tang, Min Yan, John H. Zhang. Intranasal prosaposin attenuates neuronal apoptosis through GPR37/Akt/ASK1 pathway in MCAO rats. Exp Neurol 2024. https://pubmed.ncbi.nlm.nih.gov/38114054/ 

23. Wen Zheng, Nathanael Matei, Jinwei Pang, Xu Luo, Jiping Tang, and John H. Zhang. Delayed recanalization at 3 days after permanent MCAO attenuates neuronal apoptosis through FGF21/FGFR1/PI3K/Caspase-3 pathway in rats. Experimental Neurology. 2019. https://www.ncbi.nlm.nih.gov/pubmed/31295445 

24. Tyler C. Hillman, Nathanael Matei, Jiping Tang, John H. Zang. Developing a standardized system of exposure and intervention endpoints for isoflurane in preclinical stroke models. 2018 Medical Gas Research. 2019. https://pubmed.ncbi.nlm.nih.gov/30950418/ 

25. Zhenhua Zhou, MD, PhD; Ningbo Xu, MD, PhD; Nathanael Matei, PhD; Qiongzhen Huang, MD; Jiping Tang, MD; John H. Zhang, MD, PhD. Intranasal administration of butyrate attenuates neuronal apoptosis via GPR41/Gβγ/PI3K-Akt pathway after MCAO in rats. 2020. JCBFM. https://doi.org/10.1177/0271678X20910533 

26. Zhenhua Zhou, Ningbo Xu; Jing Peng; Desislava M Doycheva; Yi He; Qiongzhen Huang; Wei Chen; Nathanael Matei; Jun Ding; Kangning Chen. Establishment of Carotid Artery Dissection and MRI Findings in a Swine Model. Frontiers Neurology. 2020.  www.frontiersin.org/articles/10.3389/fneur.2021.669276/full

27. Jinwei Pang; Jianhua Peng; Nathanael Matei; Ping Yang; Li Kuai; Yue Wu; Ligang Chen; Michael P. Vetik; Fengqiao Li; xiaochuan Sun; John H. Zhang; Yong Jiang. Apolipoprotein E exerts a whole-brain protective property by promoting M1 microglia quiescence after experimental subarachnoid hemorrhage in mice. Translational Stroke Research. Transl Stroke Res. 2018 Dec 9(6):654-668. https://pubmed.ncbi.nlm.nih.gov/30225551/ 

28. Richard Camara, Nathanael Matei, Justin Camara, Budbazar Enkhjargal, Jiping Tang, John H. Zhang. Hydrogen gas therapy improved survival rate and neurological deficits in SAH rats. 2018 Medical Gas. https://pubmed.ncbi.nlm.nih.gov/31249255/ 

29. Yu J1, Li X1, Matei N2, McBride D3, Tang J2, Yan M4, Zhang JH5. Ezetimibe, a NPC1L1 inhibitor, attenuates neuronal apoptosis through AMPK dependent autophagy activation after MCAO in rats. Exp Neurol. 2018 Sep ;307:12-23. https://pubmed.ncbi.nlm.nih.gov/29852178/ 

30. Zhiyi Xie, Budbazar Enkhjargal, Matei Nathanael, Lingyun Wu, Qiquan Zhu, Tong yu Zhang, Xin Hu, Jiping Tang, Chao You, John H. Zhang. Exendin-4 Preserves Blood-Brain Barrier Integrity via Glucagon-Like Peptide 1 Receptor/Activated Protein Kinase-Dependent Nuclear Factor-Kappa B/Matrix Metalloproteinase-9 Inhibition After Subarachnoid Hemorrhage in Rat. Journal of Cerebral Blood Flow and Metabolism. 317379. 2021. Frontiers in Molecular Neuroscience. https://pubmed.ncbi.nlm.nih.gov/35002615/ 

31. Hu Q, Manaenko A, Matei N, Guo Z, Xu T, Tang J, Zhang JH. Hyperbaric oxygen preconditioning: a reliable option for neuroprotection. Med Gas Res. 2016 Apr 4;6(1):20-32. eCollection 2016 Mar. Review. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075679/

32. Yang P, Wu J, Miao L, Manaenko A, Matei N, Zhang Y, Xu L, Pearce WJ, Hartman RE, Obenaus A, Zhang JH, Xu F, Tang J. Platelet-Derived Growth Factor Receptor-β Regulates Vascular Smooth Muscle Cell Phenotypic Transformation and Neuroinflammation After Intracerebral Hemorrhage in Mice. Crit Care Med. 2016 Jun; 44(6): e390-402. https://pubmed.ncbi.nlm.nih.gov/26646459/ 

33. Guo ZN, Xu L, Hu Q, Matei N, Yang P, Tong LS, He Y, Guo Z, Tang J, Yang Y, Zhang JH. Hyperbaric Oxygen Preconditioning Attenuates Hemorrhagic Transformation Through Reactive Oxygen Species/Thioredoxin-Interacting Protein/Nod-Like Receptor Protein 3 Pathway in Hyperglycemic Middle Cerebral Artery Occlusion Rats. Crit Care Med. 2016 Jun; 44(6): e403-11. https://pubmed.ncbi.nlm.nih.gov/26646457/ 

34. McBride DW, Matei N, Câmara JR, Louis JS, Oudin G, Walker C, Adam L, Liang X, Hu Q, Tang J, Zhang JH. Acute Hyperglycemia Does Not Affect Brain Swelling or Infarction Volume After Middle Cerebral Artery Occlusion in Rats. Acta Neurochir Suppl. 2016; 121:251-5. doi: 10.1007/978-3-319-18497-5_44. https://link.springer.com/chapter/10.1007/978-3-319-18497-5_44 

35. Chen S, Chen Y, Xu L, Matei N, Tang J, Feng H, Zhang J. Venous system in acute brain injury: Mechanisms of pathophysiological change and function. Exp Neurol. 2015 Oct; 272:4-10. doi: 10.1016/j.expneurol.2015.03.007. Epub 2015 Mar 14. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4569542/ 

36. Ravi Goyal, John V Wickle, Dipali Goyal, Nathanael Matei, Lawrence D. Longo, “Antenatal Maternal Long-Term Hypoxia: Acclimatization Responses with Altered Gene Expression in Ovine Fetal Carotid Arteries,” PLoS One. 2013 Dec 18;8(12): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3867347/  

Skills

In-Vivo Models (Surgical Skills)

Stroke – Middle Cerebral Artery Occlusion in rats (intraluminal suture: permanent, transient, transient with hemorrhagic transformation, photothrombosis), Subarachnoid Hemorrhage in rats (endovascular perforation), Intracerebral Hemorrhage in mice and rats.

Neurofunctional Tests

Sensorimotor – Modified Garcia Neuroscore for Ischemic and Hemorrhagic Strokes, Composite Neuroscore for Cerebellar Hemorrhage, Beam Balance, Foot Fault, Rotorod, Corner Turn Test, Forelimb Placement Test, Cylinder Test, Adhesive Removal Test, Wire Hang Test

Cognitive – Water Maze, T-Maze/Y-Maze, Novel Object Recognition

Anxiety – Open Field, Elevated Plus Maze, Elevated Zero Maze, Forced Swim

Imaging Modalities (Standard and Video Imaging)

Microscopy – Bright field, Phase contrast, DIC, Dark field, Fluorescence/Confocal 

Engineering Software

Graphing, Statistical Analysis, and Data Fitting – SigmaPlot®, GraphPad®

Image Analysis –ImageJ

Laboratory Equipment and Skills

Membrane separations and filtration

Immunohistochemistry

Molecular Biology Techniques – Western blot, ELISA, PCR

Maintain and troubleshooting of laboratory equipment  

Ultrafiltration/diafiltration

pH samples and protein concentration assays